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Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation

DCA Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation Kumar A, Kant S, Singh SM. Chem Biol Interact. 2012;199:29-3730 July 2012 Pyruvate dehydrogenase kinase (PDK)… Leggi tutto »Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis

MCT1 Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis Sonveaux P, Copetti T, De Saedeleer CJ, Végran F, Verrax J, Kennedy KM, Moon EJ, Dhup S, Danhier P, Frérart F, Gallez B, Ribeiro… Leggi tutto »Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis

Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes

CD8 Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes Calcinotto A, Filipazzi P, Grioni M, Iero M, De Milito A, Ricupito A, Cova A, Canese R, Jachetti E, Rossetti M, Huber V, Parmiani G, Generoso… Leggi tutto »Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes