TWH Common responses of tumors and wounds to hypoxia Payen VL, Brisson L, Dewhirst MW, Sonveaux P Cancer J.1 April 2015Hypoxia is a characteristic of tumors and wounds. Hypoxic cells develop 2 common strategies to face hypoxia: the glycolytic switch… Leggi tutto »Common responses of tumors and wounds to hypoxia
NADH NADH-linked metabolic plasticity of MCF-7 breast cancer cells surviving in a nutrient-deprived microenvironment Otto A, Hintermair J, Janzon C J Cell Biochem24 January 2015Characteristic of the tumor microenvironment are fluctuating gradients of reduced nutrient levels and released lactate. A… Leggi tutto »NADH-linked metabolic plasticity of MCF-7 breast cancer cells surviving in a nutrient-deprived microenvironment
PH Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question Khalid O. Alfarouk, Daniel Verduzco, Cyril Rauch, Abdel Khalig Muddathir, Adil H. H. Bashir, Gamal O. Elhassan, Muntaser E.… Leggi tutto »Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question
LA Impairment of Lysosomal Activity as a Therapeutic Modality Targeting Cancer Stem Cells of Embryonal Rhabdomyosarcoma Cell Line RD Salerno M, Avnet S, Bonuccelli G, Hosogi S, Granchi D, Baldini N. PLoS One.20 October 2014Rhabdomyosarcoma is the most frequent soft… Leggi tutto »Impairment of Lysosomal Activity as a Therapeutic Modality Targeting Cancer Stem Cells of Embryonal Rhabdomyosarcoma Cell Line RD
MSC Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells Gloria Bonuccelli, Sofia Avnet, Giulia Grisendi, Manuela Salerno, Donatella Granchi, Massimo Dominici, Katsuyuki Kusuzaki, Nicola Baldini Oncotarget15 September 2014The tumor microenvironment plays an important role in… Leggi tutto »Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells
MET A mitochondrial switch promotes tumor metastasis Porporato PE, Payen VL, Pérez-Escuredo J, De Saedeleer CJ, Danhier P, Copetti T, Dhup S, Tardy M, Vazeille T, Bouzin C, Feron O, Michiels C, Gallez B, Sonveaux P. Cell Rep.7 August 2014Metastatic… Leggi tutto »A mitochondrial switch promotes tumor metastasis
CA9 Expression pattern of carbonic anhydrase IX in Medullary thyroid carcinoma supports a role for RET-mediated activation of the HIF pathway Takacova M, Bullova P, Simko V, Skvarkova L, Poturnajova M, Feketeova L, Babal P, Kivela AJ, Kuopio T, Kopacek… Leggi tutto »Expression pattern of carbonic anhydrase IX in Medullary thyroid carcinoma supports a role for RET-mediated activation of the HIF pathway
OXS Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress Lamonte G, Tang X, Chen JL, Wu J, Ding CK, Keenan MM, Sangokoya C, Kung HN, Ilkayeva O, Boros LG, Newgard CB, Chi JT. Cancer Metab12 February 2014BACKGROUND: A… Leggi tutto »Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress
CLR Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine: Implications for cancer therapies Pellegrini P, Strambi A, Zipoli C, Hägg-Olofsson M, Buoncervello M, Linder S, De Milito A Autophagy12 February 2014Acidic pH is an important feature of tumor microenvironment… Leggi tutto »Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine: Implications for cancer therapies
ATP V-ATPase as an effective therapeutic target for sarcomas Perut F, Avnet S, Fotia C, Baglìo SR, Salerno M, Hosogi S, Kusuzaki K, Baldini N. Exp Cell Res. 2014;320:21-32.1 January 2014Malignant tumors show intense glycolysis and, as a consequence, high… Leggi tutto »V-ATPase as an effective therapeutic target for sarcomas