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NADH-linked metabolic plasticity of MCF-7 breast cancer cells surviving in a nutrient-deprived microenvironment

NADH NADH-linked metabolic plasticity of MCF-7 breast cancer cells surviving in a nutrient-deprived microenvironment Otto A, Hintermair J, Janzon C J Cell Biochem24 January 2015Characteristic of the tumor microenvironment are fluctuating gradients of reduced nutrient levels and released lactate. A… Leggi tutto »NADH-linked metabolic plasticity of MCF-7 breast cancer cells surviving in a nutrient-deprived microenvironment

Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question

PH Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question Khalid O. Alfarouk, Daniel Verduzco, Cyril Rauch, Abdel Khalig Muddathir, Adil H. H. Bashir, Gamal O. Elhassan, Muntaser E.… Leggi tutto »Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question

Impairment of Lysosomal Activity as a Therapeutic Modality Targeting Cancer Stem Cells of Embryonal Rhabdomyosarcoma Cell Line RD

LA Impairment of Lysosomal Activity as a Therapeutic Modality Targeting Cancer Stem Cells of Embryonal Rhabdomyosarcoma Cell Line RD Salerno M, Avnet S, Bonuccelli G, Hosogi S, Granchi D, Baldini N. PLoS One.20 October 2014Rhabdomyosarcoma is the most frequent soft… Leggi tutto »Impairment of Lysosomal Activity as a Therapeutic Modality Targeting Cancer Stem Cells of Embryonal Rhabdomyosarcoma Cell Line RD

Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells

MSC Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells Gloria Bonuccelli, Sofia Avnet, Giulia Grisendi, Manuela Salerno, Donatella Granchi, Massimo Dominici, Katsuyuki Kusuzaki, Nicola Baldini Oncotarget15 September 2014The tumor microenvironment plays an important role in… Leggi tutto »Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells

Expression pattern of carbonic anhydrase IX in Medullary thyroid carcinoma supports a role for RET-mediated activation of the HIF pathway

CA9 Expression pattern of carbonic anhydrase IX in Medullary thyroid carcinoma supports a role for RET-mediated activation of the HIF pathway Takacova M, Bullova P, Simko V, Skvarkova L, Poturnajova M, Feketeova L, Babal P, Kivela AJ, Kuopio T, Kopacek… Leggi tutto »Expression pattern of carbonic anhydrase IX in Medullary thyroid carcinoma supports a role for RET-mediated activation of the HIF pathway

Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine: Implications for cancer therapies

CLR Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine: Implications for cancer therapies Pellegrini P, Strambi A, Zipoli C, Hägg-Olofsson M, Buoncervello M, Linder S, De Milito A Autophagy12 February 2014Acidic pH is an important feature of tumor microenvironment… Leggi tutto »Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine: Implications for cancer therapies