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Putting Warburg to work: how imaging of tumour acidosis could help predict metastatic potential in breast cancer

Putting Warburg to work: how imaging of tumour acidosis could help predict metastatic potential in breast cancer Br J Cancer 2021 Feb Solid tumours are often highly acidic compared to normal tissue, and tumour extracellular acidosis contributes to multiple aspects… Leggi tutto »Putting Warburg to work: how imaging of tumour acidosis could help predict metastatic potential in breast cancer

Role of New Hydrophilic Surfaces on Early Success Rate and Implant Stability: 1-Year Post-loading Results of a Multicenter, Split-Mouth, Randomized Controlled Trial

Role of New Hydrophilic Surfaces on Early Success Rate and Implant Stability: 1-Year Post-loading Results of a Multicenter, Split-Mouth, Randomized Controlled Trial Eur J Dent. 2021 Feb Objective: To compare early implant failure and implant stability of one-stage Hiossen ET III… Leggi tutto »Role of New Hydrophilic Surfaces on Early Success Rate and Implant Stability: 1-Year Post-loading Results of a Multicenter, Split-Mouth, Randomized Controlled Trial

Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release

Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release Circulation 2021 Feb Background: Kinase oxidation is a critical signaling mechanism through which changes in the intracellular redox state alter cardiac function. In… Leggi tutto »Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release

Tumor metabolism, cancer cell transporters, and microenvironmental resistance

CC Tumor metabolism, cancer cell transporters, and microenvironmental resistance Alfarouk KO J Enzyme Inhib Med Chem.6 June 2016Cancer cells reprogram their metabolic machineries to enter into permanent glycolytic pathways. The full reason for such reprogramming takes place is unclear. However,… Leggi tutto »Tumor metabolism, cancer cell transporters, and microenvironmental resistance

Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells

OST Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells T. Chano, S. Avnet, K. Husuzaki, G. Bonuccelli, P. Sonveaux, D. Rotili, A. Mai, N. Baldini Am J Cancer Res.15 May 2016The glycolytic-based metabolism of cancers… Leggi tutto »Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells

Therapeutic inhibition of mitochondrial function induces cell death in starvation-resistant renal cell carcinomas

RCC Therapeutic inhibition of mitochondrial function induces cell death in starvation-resistant renal cell carcinomas T. Isono, T. Chano, J. Yonese, T. Yuasa Scientific Reports 10 May 2016Renal cell carcinomas (RCC) have two types of cells for carbon metabolism and for… Leggi tutto »Therapeutic inhibition of mitochondrial function induces cell death in starvation-resistant renal cell carcinomas

Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism

WE Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism Angela M. Otto Cancer & Metabolism 22 March 2016Virtually everyone working in cancer research is familiar with the “Warburg effect”, i.e., anaerobic glycolysis in the presence… Leggi tutto »Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism