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RCC Therapeutic inhibition of mitochondrial function induces cell death in starvation-resistant renal cell carcinomas T. Isono, T. Chano, J. Yonese, T. Yuasa Scientific Reports 10 May 2016Renal cell carcinomas (RCC) have two types of cells for carbon metabolism and for… Leggi tutto »Therapeutic inhibition of mitochondrial function induces cell death in starvation-resistant renal cell carcinomas

WE Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism Angela M. Otto Cancer & Metabolism 22 March 2016Virtually everyone working in cancer research is familiar with the “Warburg effect”, i.e., anaerobic glycolysis in the presence… Leggi tutto »Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism

MCT Monocarboxylate transporters in the brain and in cancer Pérez-Escuredo J, Van Hée VF, Sboarina M, Falces J, Payen VL, Pellerin L, Sonveaux P BBA Mol. Cell Res. 16 March 2016Monocarboxylate transporters (MCTs) constitute a family of 14 members among… Leggi tutto »Monocarboxylate transporters in the brain and in cancer

MET Metabolic changes associated with tumor metastasis, part 2: mitochondria, lipid and amino acid metabolism Porporato PE, Payen VL, Baselet B, Sonveaux P Cell Mol. Life Sci. 8 December 2015Metabolic alterations are a hallmark of cancer controlling tumor progression and… Leggi tutto »Metabolic changes associated with tumor metastasis, part 2: mitochondria, lipid and amino acid metabolism

MET Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway Payen VL, Porporato PE, Baselet B, Sonveaux P Cell Mol. Life Sci. 4 December 2015Metabolic adaptations are intimately associated with changes in cell… Leggi tutto »Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway

GLU Lactate promotes glutaminolysis in oxidative cancer cells Pérez-Escuredo J, Dadhish RK, Dhup S, Van Hée V, Rodriguez F, Fontenille MJ, Brisson L, Porporato PE, Sonveaux P Cell Cycle 4 December 2015Oxygenated cancer cells have a high metabolic plasticity as… Leggi tutto »Lactate promotes glutaminolysis in oxidative cancer cells

CA9 Carbonic anhydrase IX inhibition is an effective strategy for osteosarcoma treatment Perut F, Carta F, Bonuccelli G, Grisendi G, Di Pompo G, Avnet S, Sbrana FV, Hosogi S, Dominici M, Kusuzaki K, Supuran CT, Baldini N Expert Opin Ther… Leggi tutto »Carbonic anhydrase IX inhibition is an effective strategy for osteosarcoma treatment

NFKB Lactate does not activate NF-κB in oxidative tumor cells Van Hée VF, Pérez-Escuredo J, Cacace A, Copetti T, Sonveaux P Front Pharmacol  Tuesday, 13 October 2015The lactate anion is currently emerging as an oncometabolite. Lactate, produced and exported by… Leggi tutto »Lactate does not activate NF-κB in oxidative tumor cells

DLTBOA The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells Pedraz-Cuesta E, Christensen S, Jensen AA, Jensen NF, Bunch L, Romer MU, Brünner N, Stenvang J, Pedersen SF BMC Cancer16 May… Leggi tutto »The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells

SEQ Metabolism and its sequelae in cancer evolution and therapy Gillies RJ, Gatenby RA. Cancer J.1 April 2015Cancers progress through a series of events that can be characterized as “somatic evolution.” A central premise of Darwinian evolutionary theory is that… Leggi tutto »Metabolism and its sequelae in cancer evolution and therapy