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Tumor metabolism, cancer cell transporters, and microenvironmental resistance

CC Tumor metabolism, cancer cell transporters, and microenvironmental resistance Alfarouk KO J Enzyme Inhib Med Chem.6 June 2016Cancer cells reprogram their metabolic machineries to enter into permanent glycolytic pathways. The full reason for such reprogramming takes place is unclear. However,… Leggi tutto »Tumor metabolism, cancer cell transporters, and microenvironmental resistance

Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells

OST Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells T. Chano, S. Avnet, K. Husuzaki, G. Bonuccelli, P. Sonveaux, D. Rotili, A. Mai, N. Baldini Am J Cancer Res.15 May 2016The glycolytic-based metabolism of cancers… Leggi tutto »Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells

Therapeutic inhibition of mitochondrial function induces cell death in starvation-resistant renal cell carcinomas

RCC Therapeutic inhibition of mitochondrial function induces cell death in starvation-resistant renal cell carcinomas T. Isono, T. Chano, J. Yonese, T. Yuasa Scientific Reports 10 May 2016Renal cell carcinomas (RCC) have two types of cells for carbon metabolism and for… Leggi tutto »Therapeutic inhibition of mitochondrial function induces cell death in starvation-resistant renal cell carcinomas

Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism

WE Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism Angela M. Otto Cancer & Metabolism 22 March 2016Virtually everyone working in cancer research is familiar with the “Warburg effect”, i.e., anaerobic glycolysis in the presence… Leggi tutto »Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism

Metabolic changes associated with tumor metastasis, part 2: mitochondria, lipid and amino acid metabolism

MET Metabolic changes associated with tumor metastasis, part 2: mitochondria, lipid and amino acid metabolism Porporato PE, Payen VL, Baselet B, Sonveaux P Cell Mol. Life Sci. 8 December 2015Metabolic alterations are a hallmark of cancer controlling tumor progression and… Leggi tutto »Metabolic changes associated with tumor metastasis, part 2: mitochondria, lipid and amino acid metabolism

Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway

MET Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway Payen VL, Porporato PE, Baselet B, Sonveaux P Cell Mol. Life Sci. 4 December 2015Metabolic adaptations are intimately associated with changes in cell… Leggi tutto »Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway