VOPQ Vibrio effector protein, VopQ, forms a lysosomal gated channel that disrupts host ion homeostasis and autophagic flux Sreelatha A, Bennett TL, Zheng H, Jiang QX, Orth K, Starai VJ. Proc Natl Acad Sci U S A.9 July 2013Defects in… Leggi tutto »Vibrio effector protein, VopQ, forms a lysosomal gated channel that disrupts host ion homeostasis and autophagic flux
HPX Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels Parks SK, Mazure NM, Counillon L, Pouysségur J J Cell Physiol 2013; 228:1854-623 July 2013The efficacy of targeting pH disruption to induce cell death in the acidic… Leggi tutto »Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels
CA9 Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including Acetazolamide in human Glioblastoma. Said HM, Hagemann C, Carta F, Katzer A, Polat B, Staab A, Scozzafava A, Anacker J, Vince GH, Flentje M, Supuran CT Bioorg Med… Leggi tutto »Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including Acetazolamide in human Glioblastoma
PNTP Effect of pantoprazole on human gastric adenocarcinoma SGC7901 cells through regulation of phospho‑LRP6 expression in Wnt/β-catenin signaling Shen W, Zou X, Chen M, Shen Y, Huang S, Guo H, Zhang L, Liu P Oncol Rep 2013;30:851-51 July 2013Recent studies… Leggi tutto »Effect of pantoprazole on human gastric adenocarcinoma SGC7901 cells through regulation of phospho‑LRP6 expression in Wnt/β-catenin signaling
PH Quantitative in-vivo characterization of intracellular and extracellular pH profiles in heterogeneous tumors: a novel method enabling multiparametric pH analysis Lutz NW, Le Fur Y, Chiche J, Pouyssegur J, Cozzone PJ. Cancer Res 2013 Jun 10 [Epub ahead of print]4… Leggi tutto »Quantitative in-vivo characterization of intracellular and extracellular pH profiles in heterogeneous tumors: a novel method enabling multiparametric pH analysis
MC The Expression of Glut-1, CAIX, and MCT4 in Mucinous Carcinoma Kim S, Jung WH, Koo JS. J Breast Cancer. 2013;16:146-52 June 2013PURPOSE: The aim of this study was to assess the expression of metabolism related proteins including glucose transporter 1 (Glut-1), carbonic… Leggi tutto »The Expression of Glut-1, CAIX, and MCT4 in Mucinous Carcinoma
CA Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells Fiaschi T, Giannoni E, Taddei ML, Cirri P, Marini A, Pintus G, Nativi C, Richichi B, Scozzafava A, Carta F, Torre E, Supuran CT, Chiarugi P.… Leggi tutto »Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells
NHE1 Regulation of the Na+/H+ Exchanger (NHE1) in Breast Cancer Metastasis Amith SR, Fliegel L. Cancer Res. 2013;73:1259-64.1 February 2013The pH gradient in normal cells is tightly controlled by the activity of various pH-regulatory membrane proteins including the isoform protein… Leggi tutto »Regulation of the Na+/H+ Exchanger (NHE1) in Breast Cancer Metastasis
HDAC Histone acetylation regulates intracellular pH McBrian MA, Behbahan IS, Ferrari R, Su T, Huang TW, Li K, Hong CS, Christofk HR, Vogelauer M, Seligson DB, Kurdistani SK. Mol Cell 2013;49:310-2124 January 2013Differences in global levels of histone acetylation occur… Leggi tutto »Histone acetylation regulates intracellular pH
HIF Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells De Saedeleer CJ, Copetti T, Porporato PE, Verrax J, Feron O, Sonveaux P. PLoS One. 2012;7:e465711 October 2012Cancer can be envisioned as a metabolic disease driven by… Leggi tutto »Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells