paolo.porporato@unito.it

Effect of pantoprazole on human gastric adenocarcinoma SGC7901 cells through regulation of phospho‑LRP6 expression in Wnt/β-catenin signaling

PNTP Effect of pantoprazole on human gastric adenocarcinoma SGC7901 cells through regulation of phospho‑LRP6 expression in Wnt/β-catenin signaling Shen W, Zou X, Chen M, Shen Y, Huang S, Guo H, Zhang L, Liu P Oncol Rep 2013;30:851-51 July 2013Recent studies… Leggi tutto »Effect of pantoprazole on human gastric adenocarcinoma SGC7901 cells through regulation of phospho‑LRP6 expression in Wnt/β-catenin signaling

Quantitative in-vivo characterization of intracellular and extracellular pH profiles in heterogeneous tumors: a novel method enabling multiparametric pH analysis

PH Quantitative in-vivo characterization of intracellular and extracellular pH profiles in heterogeneous tumors: a novel method enabling multiparametric pH analysis Lutz NW, Le Fur Y, Chiche J, Pouyssegur J, Cozzone PJ. Cancer Res 2013 Jun 10 [Epub ahead of print]4… Leggi tutto »Quantitative in-vivo characterization of intracellular and extracellular pH profiles in heterogeneous tumors: a novel method enabling multiparametric pH analysis

Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells

CA Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells Fiaschi T, Giannoni E, Taddei ML, Cirri P, Marini A, Pintus G, Nativi C, Richichi B, Scozzafava A, Carta F, Torre E, Supuran CT, Chiarugi P.… Leggi tutto »Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells

Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells

HIF Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells De Saedeleer CJ, Copetti T, Porporato PE, Verrax J, Feron O, Sonveaux P. PLoS One. 2012;7:e465711 October 2012Cancer can be envisioned as a metabolic disease driven by… Leggi tutto »Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells

Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation

DCA Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation Kumar A, Kant S, Singh SM. Chem Biol Interact. 2012;199:29-3730 July 2012 Pyruvate dehydrogenase kinase (PDK)… Leggi tutto »Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis

MCT1 Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis Sonveaux P, Copetti T, De Saedeleer CJ, Végran F, Verrax J, Kennedy KM, Moon EJ, Dhup S, Danhier P, Frérart F, Gallez B, Ribeiro… Leggi tutto »Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis