paolo.porporato@unito.it

Vibrio effector protein, VopQ, forms a lysosomal gated channel that disrupts host ion homeostasis and autophagic flux

VOPQ Vibrio effector protein, VopQ, forms a lysosomal gated channel that disrupts host ion homeostasis and autophagic flux Sreelatha A, Bennett TL, Zheng H, Jiang QX, Orth K, Starai VJ. Proc Natl Acad Sci U S A.9 July 2013Defects in… Leggi tutto »Vibrio effector protein, VopQ, forms a lysosomal gated channel that disrupts host ion homeostasis and autophagic flux

Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including Acetazolamide in human Glioblastoma

CA9 Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including Acetazolamide in human Glioblastoma. Said HM, Hagemann C, Carta F, Katzer A, Polat B, Staab A, Scozzafava A, Anacker J, Vince GH, Flentje M, Supuran CT Bioorg Med… Leggi tutto »Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including Acetazolamide in human Glioblastoma

Effect of pantoprazole on human gastric adenocarcinoma SGC7901 cells through regulation of phospho‑LRP6 expression in Wnt/β-catenin signaling

PNTP Effect of pantoprazole on human gastric adenocarcinoma SGC7901 cells through regulation of phospho‑LRP6 expression in Wnt/β-catenin signaling Shen W, Zou X, Chen M, Shen Y, Huang S, Guo H, Zhang L, Liu P Oncol Rep 2013;30:851-51 July 2013Recent studies… Leggi tutto »Effect of pantoprazole on human gastric adenocarcinoma SGC7901 cells through regulation of phospho‑LRP6 expression in Wnt/β-catenin signaling

Quantitative in-vivo characterization of intracellular and extracellular pH profiles in heterogeneous tumors: a novel method enabling multiparametric pH analysis

PH Quantitative in-vivo characterization of intracellular and extracellular pH profiles in heterogeneous tumors: a novel method enabling multiparametric pH analysis Lutz NW, Le Fur Y, Chiche J, Pouyssegur J, Cozzone PJ. Cancer Res 2013 Jun 10 [Epub ahead of print]4… Leggi tutto »Quantitative in-vivo characterization of intracellular and extracellular pH profiles in heterogeneous tumors: a novel method enabling multiparametric pH analysis

Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells

CA Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells Fiaschi T, Giannoni E, Taddei ML, Cirri P, Marini A, Pintus G, Nativi C, Richichi B, Scozzafava A, Carta F, Torre E, Supuran CT, Chiarugi P.… Leggi tutto »Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells

Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells

HIF Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells De Saedeleer CJ, Copetti T, Porporato PE, Verrax J, Feron O, Sonveaux P. PLoS One. 2012;7:e465711 October 2012Cancer can be envisioned as a metabolic disease driven by… Leggi tutto »Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells