MC Disrupting proton dynamics and energy metabolism for cancer therapy Parks SK, Chiche J, Pouyssegur J Nat Rev Cancer 2013; 13:611-62313 September 2013 Intense interest in the ‘Warburg effect’ has been revived by the discovery that hypoxia-inducible factor 1 (HIF1)… Leggi tutto »Disrupting proton dynamics and energy metabolism for cancer therapy
ACM Acidic extracellular microenvironment and cancer Kato Y, Ozawa S, Miyamoto C, Maehata Y, Suzuki A, Maeda T, Baba Y. Cancer Cell Int. 2013 Sep 3;13:89.3 September 2013Acidic extracellular pH is a major feature of tumor tissue, extracellular acidification being… Leggi tutto »Acidic extracellular microenvironment and cancer
FA Oncogenes induce the cancer-associated fibroblast phenotype: Metabolic symbiosis and “fibroblast addiction” are new therapeutic targets for drug discovery Lisanti MP, Martinez-Outschoorn UE, Sotgia F. Cell Cycle. 2013;12:2723-321 September 2013Metabolic coupling, between mitochondria in cancer cells and catabolism in stromal… Leggi tutto »Oncogenes induce the cancer-associated fibroblast phenotype: Metabolic symbiosis and “fibroblast addiction” are new therapeutic targets for drug discovery
PPI Proton pump inhibitor selectively suppresses proliferation and restores the chemosensitivity of gastric cancer cells by inhibiting STAT3 signaling pathway. Huang S, Chen M, Ding X, Zhang X, Zou X. Int Immunopharmacol. 2013;17:585-592.20 August 2013BACKGROUNDS AND AIMS: recent studies reported… Leggi tutto »Proton pump inhibitor selectively suppresses proliferation and restores the chemosensitivity of gastric cancer cells by inhibiting STAT3 signaling pathway
NAV1.5 NaV1.5 sodium channels allosterically regulate the NHE-1 exchanger and promote breast cancer cell invadopodial activity Brisson L, Driffort V, Benoist L, Poet M, Counillon L, Antelmi E, Rubino R, Besson P, Labbal F, Chevalier S, Reshkin SJ, Gore J,… Leggi tutto »NaV1.5 sodium channels allosterically regulate the NHE-1 exchanger and promote breast cancer cell invadopodial activity
MCT4 DNA methylation of the SLC16A3 promoter regulates expression of the human lactate transporter MCT4 in renal cancer with consequences for clinical outcome. Fisel P, Kruck S, Winter S, Bedke J, Hennenlotter J, Nies AT, Scharpf M, Fend F, Stenzl… Leggi tutto »DNA methylation of the SLC16A3 promoter regulates expression of the human lactate transporter MCT4 in renal cancer with consequences for clinical outcome
TRAIL Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomes Horova V, Hradilova N, Jelinkova I, Koc M, Svadlenka J, Brazina J, Klima M, Slavik J, Hyrslova Vaculova A, Andera L. FEBS… Leggi tutto »Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomes
ES V-ATPase is a candidate therapeutic target for Ewing sarcoma Avnet S, Di Pompo G, Lemma S, Salerno M, Perut F, Bonuccelli G, Granchi D, ZIni N, Baldini N. Biochim Biophys Acta 2013; 1832:1105-161 August 2013Suppression of oxidative phosphorylation combined… Leggi tutto »V-ATPase is a candidate therapeutic target for Ewing sarcoma
CHOP Inhibition of vacuolar H+ ATPase enhances sensitivity to tamoxifen via up-regulation of CHOP in breast cancer cells Jin HO, Lee YH, Kim HA, Kim EK, Noh WC, Kim YS, Hwang CS, Kim JI, Chang YH, Hong SI, Hong YJ,… Leggi tutto »Inhibition of vacuolar H+ ATPase enhances sensitivity to tamoxifen via up-regulation of CHOP in breast cancer cells
MCT4 Expression of Monocarboxylate Transporter (MCT)-4 in Colorectal Cancer and its Role: MCT4 Contributes to the Growth of Colorectal Cancer with Vascular Endothelial Growth Factor. Gotanda Y, Akagi Y, Kawahara A, Kinugasa T, Yoshida T, Ryu Y, Shiratsuchi I, Kage… Leggi tutto »Expression of Monocarboxylate Transporter (MCT)-4 in Colorectal Cancer and its Role: MCT4 Contributes to the Growth of Colorectal Cancer with Vascular Endothelial Growth Factor