paolo.porporato@unito.it

PH Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question Khalid O. Alfarouk, Daniel Verduzco, Cyril Rauch, Abdel Khalig Muddathir, Adil H. H. Bashir, Gamal O. Elhassan, Muntaser E.… Leggi tutto »Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question

LA Impairment of Lysosomal Activity as a Therapeutic Modality Targeting Cancer Stem Cells of Embryonal Rhabdomyosarcoma Cell Line RD Salerno M, Avnet S, Bonuccelli G, Hosogi S, Granchi D, Baldini N. PLoS One.20 October 2014Rhabdomyosarcoma is the most frequent soft… Leggi tutto »Impairment of Lysosomal Activity as a Therapeutic Modality Targeting Cancer Stem Cells of Embryonal Rhabdomyosarcoma Cell Line RD

MSC Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells Gloria Bonuccelli, Sofia Avnet, Giulia Grisendi, Manuela Salerno, Donatella Granchi, Massimo Dominici, Katsuyuki Kusuzaki, Nicola Baldini Oncotarget15 September 2014The tumor microenvironment plays an important role in… Leggi tutto »Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells

MET A mitochondrial switch promotes tumor metastasis Porporato PE, Payen VL, Pérez-Escuredo J, De Saedeleer CJ, Danhier P, Copetti T, Dhup S, Tardy M, Vazeille T, Bouzin C, Feron O, Michiels C, Gallez B, Sonveaux P. Cell Rep.7 August 2014Metastatic… Leggi tutto »A mitochondrial switch promotes tumor metastasis

CA9 Expression pattern of carbonic anhydrase IX in Medullary thyroid carcinoma supports a role for RET-mediated activation of the HIF pathway Takacova M, Bullova P, Simko V, Skvarkova L, Poturnajova M, Feketeova L, Babal P, Kivela AJ, Kuopio T, Kopacek… Leggi tutto »Expression pattern of carbonic anhydrase IX in Medullary thyroid carcinoma supports a role for RET-mediated activation of the HIF pathway

OXS Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress Lamonte G, Tang X, Chen JL, Wu J, Ding CK, Keenan MM, Sangokoya C, Kung HN, Ilkayeva O, Boros LG, Newgard CB, Chi JT. Cancer Metab12 February 2014BACKGROUND: A… Leggi tutto »Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress

CLR Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine: Implications for cancer therapies Pellegrini P, Strambi A, Zipoli C, Hägg-Olofsson M, Buoncervello M, Linder S, De Milito A Autophagy12 February 2014Acidic pH is an important feature of tumor microenvironment… Leggi tutto »Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine: Implications for cancer therapies

ATP V-ATPase as an effective therapeutic target for sarcomas Perut F, Avnet S, Fotia C, Baglìo SR, Salerno M, Hosogi S, Kusuzaki K, Baldini N. Exp Cell Res. 2014;320:21-32.1 January 2014Malignant tumors show intense glycolysis and, as a consequence, high… Leggi tutto »V-ATPase as an effective therapeutic target for sarcomas

NHE1 Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs – an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research. Harguindey S, Arranz JL, Polo Orozco JD, Rauch C, Fais S, Cardone RA, Reshkin… Leggi tutto »Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs – an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research

ATP Vacuolar ATPase driven potassium transport in highly metastatic breast cancer cells Salyer SA, Olberding JR, Distler AA, Lederer ED, Clark BJ, Delamere NA, Khundmiri SJ. Biochim Biophys Acta. 2013;1832:1734-43.2 October 2013 Breast cancer is the second leading cause of… Leggi tutto »Vacuolar ATPase driven potassium transport in highly metastatic breast cancer cells