MET Metabolic changes associated with tumor metastasis, part 2: mitochondria, lipid and amino acid metabolism Porporato PE, Payen VL, Baselet B, Sonveaux P Cell Mol. Life Sci. 8 December 2015Metabolic alterations are a hallmark of cancer controlling tumor progression and… Leggi tutto »Metabolic changes associated with tumor metastasis, part 2: mitochondria, lipid and amino acid metabolism
MET Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway Payen VL, Porporato PE, Baselet B, Sonveaux P Cell Mol. Life Sci. 4 December 2015Metabolic adaptations are intimately associated with changes in cell… Leggi tutto »Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway
GLU Lactate promotes glutaminolysis in oxidative cancer cells Pérez-Escuredo J, Dadhish RK, Dhup S, Van Hée V, Rodriguez F, Fontenille MJ, Brisson L, Porporato PE, Sonveaux P Cell Cycle 4 December 2015Oxygenated cancer cells have a high metabolic plasticity as… Leggi tutto »Lactate promotes glutaminolysis in oxidative cancer cells
CA9 Carbonic anhydrase IX inhibition is an effective strategy for osteosarcoma treatment Perut F, Carta F, Bonuccelli G, Grisendi G, Di Pompo G, Avnet S, Sbrana FV, Hosogi S, Dominici M, Kusuzaki K, Supuran CT, Baldini N Expert Opin Ther… Leggi tutto »Carbonic anhydrase IX inhibition is an effective strategy for osteosarcoma treatment
NFKB Lactate does not activate NF-κB in oxidative tumor cells Van Hée VF, Pérez-Escuredo J, Cacace A, Copetti T, Sonveaux P Front Pharmacol Tuesday, 13 October 2015The lactate anion is currently emerging as an oncometabolite. Lactate, produced and exported by… Leggi tutto »Lactate does not activate NF-κB in oxidative tumor cells
DLTBOA The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells Pedraz-Cuesta E, Christensen S, Jensen AA, Jensen NF, Bunch L, Romer MU, Brünner N, Stenvang J, Pedersen SF BMC Cancer16 May… Leggi tutto »The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells
SEQ Metabolism and its sequelae in cancer evolution and therapy Gillies RJ, Gatenby RA. Cancer J.1 April 2015Cancers progress through a series of events that can be characterized as “somatic evolution.” A central premise of Darwinian evolutionary theory is that… Leggi tutto »Metabolism and its sequelae in cancer evolution and therapy
TWH Common responses of tumors and wounds to hypoxia Payen VL, Brisson L, Dewhirst MW, Sonveaux P Cancer J.1 April 2015Hypoxia is a characteristic of tumors and wounds. Hypoxic cells develop 2 common strategies to face hypoxia: the glycolytic switch… Leggi tutto »Common responses of tumors and wounds to hypoxia
NADH NADH-linked metabolic plasticity of MCF-7 breast cancer cells surviving in a nutrient-deprived microenvironment Otto A, Hintermair J, Janzon C J Cell Biochem24 January 2015Characteristic of the tumor microenvironment are fluctuating gradients of reduced nutrient levels and released lactate. A… Leggi tutto »NADH-linked metabolic plasticity of MCF-7 breast cancer cells surviving in a nutrient-deprived microenvironment
PH Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question Khalid O. Alfarouk, Daniel Verduzco, Cyril Rauch, Abdel Khalig Muddathir, Adil H. H. Bashir, Gamal O. Elhassan, Muntaser E.… Leggi tutto »Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question