paolo.porporato@unito.it

Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia

Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia Oncogenesis 2021 Jan Cachexia is a severe complication of cancer that adversely affects the course of the disease, with currently no effective treatments. It is characterized by… Leggi tutto »Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia

Tumour acidosis evaluated in vivo by MRI-CEST pH imaging reveals breast cancer metastatic potential

Tumour acidosis evaluated in vivo by MRI-CEST pH imaging reveals breast cancer metastatic potential Br J Cancer 2021 Jan Background: Tumour acidosis is considered to play a central role in promoting cancer invasion and migration, but few studies have investigated in… Leggi tutto »Tumour acidosis evaluated in vivo by MRI-CEST pH imaging reveals breast cancer metastatic potential

Putting Warburg to work: how imaging of tumour acidosis could help predict metastatic potential in breast cancer

Putting Warburg to work: how imaging of tumour acidosis could help predict metastatic potential in breast cancer Br J Cancer 2021 Feb Solid tumours are often highly acidic compared to normal tissue, and tumour extracellular acidosis contributes to multiple aspects… Leggi tutto »Putting Warburg to work: how imaging of tumour acidosis could help predict metastatic potential in breast cancer

Role of New Hydrophilic Surfaces on Early Success Rate and Implant Stability: 1-Year Post-loading Results of a Multicenter, Split-Mouth, Randomized Controlled Trial

Role of New Hydrophilic Surfaces on Early Success Rate and Implant Stability: 1-Year Post-loading Results of a Multicenter, Split-Mouth, Randomized Controlled Trial Eur J Dent. 2021 Feb Objective: To compare early implant failure and implant stability of one-stage Hiossen ET III… Leggi tutto »Role of New Hydrophilic Surfaces on Early Success Rate and Implant Stability: 1-Year Post-loading Results of a Multicenter, Split-Mouth, Randomized Controlled Trial

Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release

Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release Circulation 2021 Feb Background: Kinase oxidation is a critical signaling mechanism through which changes in the intracellular redox state alter cardiac function. In… Leggi tutto »Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release